Influence of miosis and laser peripheral iridotomy on intraocular lens power calculation in patients with primary angle closure disease (2024)

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Influence of miosis and laser peripheral iridotomy on intraocular lens power calculation in patients with primary angle closure disease (1)

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Eye (Lond). 2023 Sep; 37(13): 2744–2752.

Published online 2023 Jan 27. doi:10.1038/s41433-023-02408-z

PMCID: PMC10482892

PMID: 36707639

Hongfang Yang,1,2,3 Dongjin Qian,1,2,3 Geoffrey Chan,4,5 Jiajian Wang,1,2,3 Xinghuai Sun,Influence of miosis and laser peripheral iridotomy on intraocular lens power calculation in patients with primary angle closure disease (2)1,2,3,6 and Yuhong ChenInfluence of miosis and laser peripheral iridotomy on intraocular lens power calculation in patients with primary angle closure disease (3)1,2,3

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Associated Data

Supplementary Materials
Data Availability Statement

Abstract

Objectives

To evaluate the effect of miosis and laser peripheral iridotomy (LPI) on intraocular lens (IOL) power prediction and ocular biometry in eyes with primary angle closure disease (PACD).

Methods

In this prospective observational study, primary angle closure suspects (PACS), and subjects classified with primary angle closure (PAC)/primary angle-closure glaucoma (PACG) undergoing LPI were enrolled. Ocular biometric parameters were measured with IOLMaster700 at baseline (T0), one week after pilocarpine instillation (T1), and another week post LPI (T2). Biometric changes and the IOL power predicted for emmetropia using Barrett Universal II, Haigis, Holladay2, Hoffer Q and SRK/T formulae were analysed and compared among different time points.

Results

100 eyes of 50 PACS and 50 PAC/PACG patients were enrolled. Following pilocarpine-induced miosis, lens thickness (LT) increased and anterior chamber depth (ACD) decreased (all groups p < 0.01), while white-to-white diameter decreased and central corneal thickness increased significantly only in the PACS cohort (both p < 0.01). Compared to baseline, LPI induced an increase of ACD and a slight decrease of LT in PACS (both p < 0.01), whereas only axial length changed significantly (p = 0.012) in the PAC/PACG cohort. Regardless of the formula used, no significant difference to the predicted IOL power for emmetropia existed among the three time points in each group (all p > 0.1).

Conclusion

We report the changes of anterior segment parameters induced by miosis and LPI in PACD. These interventions do not significantly affect the IOL power calculation predicted for emmetropia in Chinese eyes when common third-, fourth-and new generation IOL formulae are used.

Subject terms: Glaucoma, Outcomes research

Introduction

Primary angle closure disease (PACD) has a higher prevalence in Asian populations, with the subtype of primary angle closure glaucoma (PACG) responsible for the vast majority of glaucoma blindness in Chinese cohorts. Cataract surgery is established as an effective intervention for PACD patients, addressing multiple mechanisms in pathogeneses such as pupil block and iris crowding that stems from age-related thickening of the crystalline lens [1]. Numerous publications have highlighted the higher risk of refractive error following cataract surgery in this cohort compared to that of patients undergoing cataract surgery without anatomical features contributing to synechiae development and primary angle closure [2, 3]. It is not known whether this refractive error may be explained by interventions such as pharmacological miosis and laser peripheral iridotomy frequently employed in the management algorithm of this disease [46].

Anatomical and ocular biometric changes in response to pilocarpine are well known including pharmacological accommodation and forward movement of the iris-lenticular diaphragm. Conversely, LPI may deepen the peripheral ACD by reconstructing an aqueous humour outflow pathway [7, 8]. It may be hypothesized that changes related to miosis and LPI may alter ocular parameters critical to IOL prediction [9]. Additionally, modern IOL power calculation formulae and their ability to predict a target postoperative refraction may be affected to varying degrees depending on the variations of which different ocular parameters may be incorporated.

We performed this study to determine the biometric changes that pilocarpine and LPI may induce in subjects with PACD, and compared the IOL power prediction based on these parameters for emmetropia before and after these interventions. This current study clarifies whether these two interventions commonly performed for PACD would subsequently induce a change in IOL power calculated for emmetropia, which would potentially contribute to the increased refractive error frequently seen in this cohort of patients.

Methods

The procedures used in this study conformed to the tenets of the Declaration of Helsinki for Research Involving Human Participants and was approved by the Ethical Review Committee of Eye & ENT Hospital of Fudan University, a tertiary specialized hospital in Shanghai of China. The trial protocol was also registered at ChiCTR (www.chictr.org, Registration Number: ChiCTR2100051681). All participants were Han Chinese and provided written informed consent to participate in the study.

This prospective observational study recruited 50 eyes of 50 PACS patients and 50 eyes of 50 PAC or PACG patients diagnosed at the Eye & ENT Hospital of Fudan University from April 2020 to January 2022. Diagnoses were made by a fellow trained in glaucoma (H.Y.) and confirmed by one of the senior glaucoma consultants (Y.C. and J.W.) according to the International Society for Geographical and Epidemiological Ophthalmology (ISGEO) guidelines [10]. In brief, PACS was defined as eyes in which at least 180° of the posterior pigmented trabecular meshwork was not visible on gonioscopy in the primary position of gaze without indentation but with neither increased IOP nor glaucomatous neuropathy. People meeting gonioscopic criteria for PACS and with evidence of peripheral anterior synechia or increased IOP (greater than 22 mmHg) would be classified as primary angle closure (PAC). Those PAC who additionally demonstrated glaucomatous damage of the optic nerve were classified as primary angle closure glaucoma (PACG).

Exclusion criteria included the presence of corneal oedema, acute angle closure crisis, baseline IOP more than 30 mmHg, plateau iris, secondary angle closure, a dense cataract influencing the quality of optical biometry, severe fundus abnormalities, poor fixation, strabismus, contact lens wear, or any history of ocular trauma or prior intraocular surgery. A history of systemic or topical medication that could affect ocular accommodation was also excluded. If both eyes of one subject were eligible for enrolment, the eye with more extensive angle closure or iridotrabecular contact was selected for study inclusion.

A comprehensive medical history review and ocular examination including uncorrected visual acuity (UCVA), slit lamp examination, ophthalmoscopy, gonioscopy, ultrasound biomicroscopy (UBM), and intraocular pressure (IOP) measurement was performed. For those with normal IOP and vertical CDR ≥ 0.6, careful evaluation on the retinal nerve fibre layer was performed by one of the glaucoma consultants (Y.C., and J.W.). Patients with controversy would receive further visual field tests until final diagnoses were agreed by the three authors (H.Y., Y.C., and J.W.). All participants were prescribed with pilocarpine nitrate 0.5% (Zhenrui®, Bausch+Lomb) three times per day and scheduled for LPI one week after. LPI was routinely performed by trained doctors, under topical anaesthesia using a VOLK iridectomy laser lens with single pulsed Neodymium: Yttrium Aluminum Garnet (Nd: YAG) laser at an initial setting of 8.0–10.0 mJ to create a patent iridotomy. After the procedure, 1% Prednisolone Acetate ophthalmic suspension (Pred Forte®, Allergan) was prescribed four times a day for one week.

Optical biometry was performed using IOLMaster700® (Carl Zeiss Meditec, Jena, Germany) at the following time points: (1) at baseline (T0), (2) one week after instillation of pilocarpine nitrate 0.5% before LPI (T1), and (3) another 7 days post LPI (T2). Specifically, at T1, a horizontal pupil diameter less than 3.0 mm and the pupillary-light reflex masked completely by the pilocarpine-induced miosis were confirmed before biometry. Similarly, restoration of the pupil light reflex and pupil diameter were documented, and a patent iridotomy was confirmed before measurement at T2.

Three biometric measurements were obtained at each time point by one experienced technician (D.Q.) to confirm reproducibility of results. The quality control criteria were applied as per manufacturer recommendations. Foveal fixation and good corneal exposure during measurement were further confirmed retrospectively (by Dr. H.Y.). The axial length (AL), the mean keratometry (average of steepest and flattest anterior keratometry, mean K), the central corneal thickness (CCT), corneal diameter (white-to-white distance, WTW), the anterior chamber depth (ACD), the lens thickness (LT) and pupil size were measured for all patients. The IOL powers predicted for emmetropia based on the TECNIS® Monofocal 1-Piece Model ZCB00 lens were calculated with multiple formulae including the Barrett Universal II, Haigis, Holladay 2, Hoffer Q and SRK/T. The lens constants were selected based on the optimized values for the IOLmaster700® and specifically for the ZCB00 lens as listed on the User Group for Laser Interference Biometry (ULIB) website (http://ocusoft.de/ulib/czm/index.htm).

Statistics

Sample size were calculated using G*Power software (version 3.0.1.9, Dusseldorf, Germany). After choosing F test and the ANOVA test with repeated measurements and within factors, required variable were set as follows: a medium effect size of 0.25 as Cohen suggested; the α level at 0.05; the power (1-β) at 0.8; number of groups = 2 and number of measurements = 3; correlation among repeated measurements set at 0 initially, and nonsphericity correction = 1/(3–1) = 0.5. The calculation results showed that the sample size required per group was 43. We enrolled 50 eyes in each group finally.

One-way repeated measures ANOVA of the General Linear Model (GLM) procedure was used to analyse the differences of each measured parameter and the IOL power prediction for emmetropia at baseline, after the usage of pilocarpine and post-LPI. The Shapiro-Wilk normality test was used to examine the normal distribution assumption, and the Mauchly’s test of sphericity was used to assess whether or not the assumption of sphericity was met. When the sphericity assumption was violated (i.e., Mauchly’s test p < =0.05), the Greenhouse-Geisser correction was used, particularly when epsilon <0.75, and the results were interpreted from the sphericity corrections table. Significant intervention effects were tested by a Bonferroni-adjusted pairwise post hoc analysis. If the normality distribution was violated, Wilcoxon Signed rank test was conducted instead of T test. Fisher’s exact test was used to determine if there was a significant difference of the proportion of eyes with IOL power estimation differing by greater than 0.5D between groups. Statistical significance was defined as p < 0.05. All statistical analysis was performed using IBM® SPSS® Statistics 26.0. Continuous data were presented as mean ± standard deviation (SD) unless otherwise stated.

Results

A total of 50 PACS and 50 PAC/PACG (including 46 with PAC and 4 with PACG) patients were enrolled in the study. The mean age of all patients was 63.2 ± 8.47 years (mean ± SD) and 16% of patients were male. The clinical characteristics of the patients are shown in Table1. Patients with PAC/PACG were prescribed intraocular pressure lowering eyedrops, i.e., brimonidine tartrate 0.15%, Brinzolamide 1% and/or Timolol Maleate 0.5%, and continued using them during the study duration. The Shapiro-Wilk normality tests showed that all the numerical parameters studied were normally distributed except IOP in the PAC/PACG group. The mean AL, ACD, LT, CCT, WTW and mean K at baseline were 22.27 ± 0.77 mm, 2.42 ± 0.26 mm, 4.88 ± 0.32 mm, 538.5 ± 28.14 μm, 11.59 ± 0.37 mm, and 44.80 ± 1.58D, respectively. There were no significant differences between the two groups on these baseline ocular biometers except ACD (2.46 ± 0.24 mm in PACS vs 2.31 mm ± 0.22 mm in PAC/PACG, P = 0.002).

Table 1

Clinical characteristics of enrolled patients in each group.

PACSPAC/PACG
Age (y)62.82 (9.06)62.24 (7.10)
Gender
Male5 (10%)11 (22%)
Female45 (90%)39 (78%)
Uncorrected Visual Acuitya0.25 (0.23)0.28 (0.32)
Synechial Angle Closure (degree)b090 (10–315)
C/D ratiob0.4 (0.2–0.7)0.4 (0.3–0.9)

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Continuous variables were expressed as means (SD) and count variables as numbers (percentages).

aUncorrected visual acuity was recorded in LogMAR Equivalent and expressed as means (SD).

bExtent of angle closure and C/D ratio were both expressed as median (range).

Effects of miosis and LPI on ocular biological parameters

The pupil diameter reduced from 3.71 ± 0.70 mm to 1.79 ± 0.29 mm (p < 0.001) after instillation of 0.5% pilocarpine nitrate three times per day for one week (T1), and increased back to 3.84 ± 0.64 mm (p = 0.11 compared with baseline) one week after LPI with cessation of pilocarpine (T2). The effect of pilocarpine and LPI on the ocular biometers and intraocular pressure (IOP) are shown in Fig.1 and Table2. There was no significant change of the IOP one week after LPI compared to the baseline IOP in either group (p = 0.307 for PACS, and 0.059 for PAC/PACG). The changes in all the measured parameters did not exhibit a significant time–group interaction except AL (p > 0.05 for pupil, ACD, LT, CCT, WTW, mean K, and p = 0.004 for AL, repeated-measures ANOVA), indicating similar changing trends of all the involved parameters, except AL, between PACS and PAC/PACG group along the three time points.

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Fig. 1

Comparisons of the changes in ocular parameters along three timepoints between PACS and PAC/PACG.

AH showed the variation of means of pupil diameter, central anterior chamber depth (ACD), lens thickness (LT), axial length (AL), ratio of LT/AT, mean of anterior keratometry, white-to-white (WTW) diameter and central corneal thickness (CCT) among the three time points (baseline, under miosis using pilocarpine and after LPI) in PACS (solid line) and PAC/PACG (dashed line), respectively. Error bar = +/−2SE; *indicates p < 0.05 and **indicates p < 0.001 when Bonferroni-adjusted post hoc pairwise comparisons was conducted. In PACS group: pilocarpine induced significant change of ACD, LT, WTW, and CCT, while LPI deepened ACD and thinned LT. For the PAC/PACG group, pilocarpine only reduced ACD and LT, whereas LPI shortened AL.

Table 2

Effect of miosis and LPI on ocular biological parameters and IOP.

Biological ParametersBaseline [T0]Post-pilocarpine [T1]Post-LPI [T2]P1 valueP2 valueP3 valueP4 value
PACSPAC/PACGTotalPACSPAC/PACGTotalPACSPAC/PACGTotal
IOP (mmHg)a

15.7 ± 3.45

[14.7, 16.7]

16.0

(11.4, 30.0)

16.3

(7.9, 30.0)

N/AN/AN/A

16.3 ± 3.26

[15.3, 17.2]

15.8

(8.9, 30.0)

16.0

(7.9, 30.0)

0.279N/A0.3070.059
PD (mm)

3.7 ± 0.65

[3.5, 3.9]

3.7 ± 0.69

[3.5, 3.9]

3.7 ± 0.67

[3.6, 3.8]

1.7 ± 0.24

[1.6, 1.8]

1.9 ± 0.30

[1.8, 1.9]

1.8 ± 0.28

[1.7, 1.8]**

3.8 ± 0.58

[3.6, 3.9]

3.9 ± 0.70

[3.7, 4.1]

3.8 ± 0.64

[3.7, 4.0]

<0.0010.725<0.001<0.001
ACD (mm)

2.46 ± 0.240

[2.39, 2.53]

2.32 ± 0.216

[2.26, 2.38]##

2.39 ± 0.238

[2.34, 2.44]

2.39 ± 0.231

[2.33, 2.46]**

2.26 ± 0.216 [2.20, 2.33]##,**2.33 ± 0.232 [2.28, 2.37]**

2.47 ± 0.245

[2.41, 2.54]**

2.33 ± 0.213

[2.26, 2.39]##,ф

2.40 ± 0.241

[2.35, 0.45]**

<0.0010.086<0.001<0.001
LT (mm)

4.85 ± 0.313

[4.76, 4.94]

4.96 ± 0.364

[4.85, 5.06]

4.90 ± 0.342

[4.84, 4.97]

4.88 ± 0.312

[4.80, 4.97]**

5.00 ± 0.363 [4.88, 5.09]**4.94 ± 0.341 [4.87, 5.00]**

4.84 ± 0.313

[4.75, 4.93]**

4.96 ± 0.369

[4.85, 5.06]ф

4.90 ± 0.345

[4.83, 4.97]

<0.0010.075<0.001<0.001
CCT (μm)

540 ± 25.8

[532, 547]

545 ± 29.6

[536, 553]

542 ± 27.7

[537, 548]

543 ± 24.60

[536, 550]**

547 ± 30.25

[538, 556]

545 ± 27.5

[539, 550]*

539 ± 24.5

[532, 546]ф

542 ± 30.5

[533, 551]ф

541 ± 27.5

[535, 546]

<0.0010.3530.0020.005
WTW (mm)

11.6 ± 0.38

[11.5, 11.7]

11.5 ± 0.43

[11.4, 11.7]

11.6 ± 0.40

[11.5, 11.6]

11.5 ± 0.35

[11.4, 11.6]**

11.5 ± 0.37

[11.4, 11.6]

11.5 ± 0.36

[11.4, 11.5]**

11.6 ± 0.41

[11.5, 11.7]ф

11.5 ± 0.41

[11.4, 11.6]

11.5 ± 0.41

[11.4, 11.6]

<0.0010.2650.0010.052
Mean K (D)

44.65 ± 1.691

[44.16, 45.13]

44.42 ± 1.609

[43.95, 44.88]

44.53 ± 1.646

[44.20, 44.86]

44.65 ± 1.683

[44.17, 45.13]

44.37 ± 1.611 [43.91, 44.84]

44.51 ± 1.645

[44.18, 44.84]

44.68 ± 1.700 [44.20, 45.17]

44.41 ± 1.658

[43.93, 44.89]

44.54 ± 1.677

[44.21, 44.88]

0.2780.2640.4020.105
AL (mm)

22.32 ± 0.786

[22.10, 22.54]

22.42 ± 0.821

[22.18, 22.65]

22.37 ± 0.801

[22.21, 22.53]

22.33 ± 0.783

[22.10, 22.55]

22.42 ± 0.818

[22.18, 22.65]

22.37 ± 0.798

[22.21, 22.53]

22.32 ± 0.786

[22.10, 22.55]

22.40 ± 0.829

[22.16, 22.64]*,#,ф

22.36 ± 0.804

[22.20, 22.52]*

0.0020.0040.0970.001
LT/AL ratio

0.22 ± 0.016

[0.21, 0.22]

0.22 ± 0.018

[0.22, 0.23]

0.22 ± 0.017

[0.22, 0.22]

0.22 ± 0.016

[0.21, 0.22]**

0.22 ± 0.018

[0.22, 0.23]**

0.22 ± 0.017

[0.22, 0.22]**

0.22 ± 0.016

[0.21, 0.22]*

0.22 ± 0.019

[0.22, 0.23]

0.22 ± 0.017

[0.22, 0.22]

<0.0010.011<0.001<0.001

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Measured results were presented as Mean ± Standard Deviation [95% confidence interval], except IOP of PAC/APCG group and total participants as Median (Minimum, Maximum) for their abnormal distribution.

IOP intraocular pressure, PD pupil diameter, ACD anterior chamber depth, LT lens thickness, CCT central corneal thickness, WTW white to white, K keratometry, AL axial length, LT/AL lens thickness/axial length.

P1: Significance of difference among three time points in total.Bold values indicated significant differences based on p value.

P2: Significance of changing pattern between groups.Bold values indicated significant differences based on p value.

P3: Significance of difference among three time points in group PACS.Bold values indicated significant differences based on p value.

P4: Significance of difference among three time points in group PAC/PACG.Bold values indicated significant differences based on p value.

*Indicated p < 0.05, while **indicated p < 0.01 for measurements after intervention compared with that measured at baseline.

#Indicated p < 0.05 and ##indicated p < 0.01 when measurements compared between the two groups at each time point.

фIndicated p < 0.05 for measurements after LPI compared to that measured under miosis.

aCompared using paired samples T-test for PACS group, and related samples Wilcoxon signed rank test for PAC/PACG group for its non-normal distribution.

Generally, pilocarpine instillation induced a significant decrease of ACD by 0.07 ± 0.057 mm in PACS group and by 0.06 ± 0.055 mm in PAC/PACG (both p < 0.001), along with a significant increase of LT (by 0.03 ± 0.022 mm and 0.03 ± 0.023 mm in the two groups, respectively, both p < 0.01) and of LT/AL in both groups (by 0.0015 ± 0.00098 and 0.0014 ± 0.00120, respectively, both p < 0.01). Additionally, WTW decreased by 0.09 ± 0.151 mm (p < 0.001) and CCT increased by 3.1 ± 6.52 μm (p = 0.006) significantly under miosis in PACS patients but not change in PAC/PACG patients (p = 0.06 for WTW & p = 0.561 for CCT).

Compared to baseline, LPI had no effect on WTW and CCT in either group (all p > 0.1), but deepened the ACD by 0.01 ± 0.023 mm (p < 0.001), reduced the lens thickness by 0.01 ± 0.015 mm (p = 0.004) and reduced the LT/AL by 0.0004 ± 0.00079 (p = 0.005) significantly in the PACS group. LPI induced a small but significant shortening of the AL in the PAC/PACG cohort (△ = −0.017 ± 0.051 mm, p = 0.012). Neither pilocarpine instillation nor LPI changed the mean keratometry of the anterior corneal surfaces significantly (p = 0.402 for PACS and p = 0.105 for PAC/PACG).

ACD and LT changes induced by either pilocarpine or LPI did not show any correlation with the ACD and LT at the baseline in both groups (Pearson’s rho = −0.265, 0.212, −0.097, −0.038, all p > 0.05 for PACS; Pearson’s rho = −0.126, −0.155, 0.024, 0.106, and all p > 0.2 for PAC/PACG).

Effects of miosis and LPI on the IOL power calculation

The mean IOL powers predicted for emmetropia by numerous IOL calculation formulae at baseline (T0), under miosis (T1) and after LPI (T2) for each group are shown in Table3. The predicted IOL power decreased by a mean of 0.04D~0.10D after either treatment in the PACS group, whereas it increased by an averaged 0.04D~0.08D in the PAC/PACG group (Supplementary Material1), which demonstrated a different pattern of change between the two groups along the three time points with all the involved formulae except Holladay 2 (p = 0.083). Nevertheless, no statistically significant difference was detected before and after either treatment in each group (all the p > 0.5). (Table3) Additionally, the proportion of eyes with a change of IOL power estimation more than 0.5D in each group was presented by formula in Supplementary Material2. Briefly, there were 2–5 eyes (4–10%) with IOL power changing over 0.5D in each group, and the proportion did not differ neither between PACS and PAC/PACG nor among various formulas. Cumulatively, these results demonstrated that IOL power prediction by various IOL calculation formulae was not affected by the effect of pharmacological miosis or LPI in PACD patients (Fig.2).

Table 3

Effects of miosis and LPI on the ZCB00 IOL power calculation for emmetropia in PACS and PAC/PACG.

FormulaeIOL power predicted for emmetropia
Pre-interventionPost-pilocarpinepost-LPISignificance of changing pattern between groupsDifference among time points in PACSDifference among time points in PAC/PACGTotal
PACSPAC/PACGTotalPACSPAC/PACGTotalPACSPAC/PACGTotalP-valueP-valueP-valueP-value
Third Generation

SRK/T

(Aconst = 119.3)

24.56 (1.89)24.43 (1.77)24.49 (1.82)24.52 (1.93)24.48 (1.77)24.50 (1.84)24.49 (1.87)24.50 (1.75)24.50 (1.81)0.0060.1350.041a0.942

Hoffer Q

(pACD = +5.80)

24.85 (2.12)24.75 (1.92)24.80 (2.01)24.80 (2.18)24.82 (1.92)24.81 (2.04)24.77 (2.11)24.84 (1.90)24.80 (2.00)0.0090.1490.0540.926
Fourth Generation

Haigis

(a0 = −1.302 a1 = +0.21 a2 = +0.251)

24.35 (1.95)24.21 (1.75)24.28 (1.85)24.27 (2.01)24.25 (1.75)24.26 (1.88)24.27 (1.93)24.29 (1.74)24.28 (1.83)0.0130.120.0760.731

Holladay 2

(ACD = + 5.786)

24.49 (2.01)24.29 (1.89)24.39 (1.94)24.45 (2.03)24.34 (1.88)24.39 (1.95)24.45 (1.98)24.39 (1.86)*24.42 (1.91)0.0830.6330.0320.522
New Generation

Barrett Universal II

(LensFactor = 2.09 DesignFactor = 4)

24.25 (2.01)24.18 (1.83)24.22 (1.91)24.20 (2.10)24.23 (1.86)24.22 (1.97)24.20 (2.00)24.27 (1.82)24.23 (1.90)0.0420.3660.070.829

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The predicted IOL power was presneted as mean (SD). Bold values indicated significant differences based on p value.

*Indicated p < 0.05 for IOL power different from that predicted at baseline (T0).

aRepeated measures ANOVA showed there was significant differences among the IOL power predicted in PAC/PACG group using SRK/T, but Bonferroni-adjusted pairwise post hoc comparison did not reveal any significant difference between any two of the three time points.

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Fig. 2

Comparisons between PACS and PAC/PACG in terms of the changing pattern of IOL power prediction along three timepoints with various formulae.

AE showed the different patterns of IOL power predicted for emmetropia in PACS (solid line) and PAC/PACG (dashed line) group along the three time points (baseline, under miosis using pilocarpine and post LPI), calculated with various generation formulae. A and B presented results with the 3rd generation formulae (SRK/T and Hoffer Q, respectively); (C, D) showed that with the 4th generation formulae (Haigis and Holladay 2, respectively); (E) was the result from the new generation Barrett Universal II formula. Error bar = +/−2SE; solid star indicates statistical difference during pairwise comparison among the three statuses (p < 0.05), which means only the calculation results in PAC/APCG using Holladay2 was different between baseline and post-LPI significantly. Generally, insignificant difference was found either among different formulae or among different time points.

Discussion

According to European Glaucoma Society Terminology and Guidelines for Glaucoma (5th Edition), prompt lens extraction is advisable for PAC or PACG patients with cataract [11]. LPI and pilocarpine are also important parts of the management algorithm for patients with PACD, especially among the subtypes of PACS and PAC. It has been proposed that the measurement of the phakic anterior chamber depth with pharmacological stimulation (non-physiologic state) of the ciliary muscle would induce a statistical error for IOL power calculation [5]. This study indicated that biometric changes induced by either miosis or LPI had little impact on IOL power calculation among PACD patients.

The use of pilocarpine resulted in lens thickening and shallowed anterior chamber depth in both groups of our study. In addition, our results also showed that corneal diameter decreased and CCT increased after miosis (Table2; Fig.1, and Supplementary Material1). The reduction of corneal diameter during miosis was perhaps attributed to a centripetal contractive force of ciliary muscle acting on the scleral spur [7] and the peripheral cornea, whereas further investigation is warranted. As regards the CCT, Gupta and associates [12] have also observed an increased mean CCT after pilocarpine in PACS patients, although statistically insignificant. According to Kahori et al. [13], changes of corneal thickness depend on various factors, and they attributed the increased CCT observed in their study to eyelid closure after eye drops instillation before measurements. Whereas, Talajic et al. [7] imputed it to the hydrostatic pressure on the corneal endothelium secondary to the IOP changes induced by interventions. Considering that our patients did not use pilocarpine or anti-glaucoma eye drops immediately prior to measurements, Kahori’s hypothesis does not apply to us. Nevertheless, since we did not measure patients’ IOP after pilocarpine instillation, the cause of CCT increase in PACS patients under miosis is yet to be elucidated.

Theoretically, LPI eliminates relative pupillary block and equalizes the pressure in the anterior chamber and posterior chamber. Compared to baseline, prophylactic LPI affected neither WTW nor CCT but deepened ACD and resulted in a thinner lens measurement in our PACS group, which was consistent with findings from previous studies [12, 1416]. This may be due to more aqueous humour flowing into the anterior chamber through the peripheral iridotomy, pushing the lens backward and flattening the anterior curvature of lens [6], resulting in reduced lens thickness. However, such subtle alterations were not detected in our PAC/PACG group. One explanation is that PACS patients arranged for LPI in our study presented with critical bowing of the iris, which resulted in a posterior shift of the iris and deepening of the ACD after LPI once pupillary block was relieved. In contrast, PAC/PACG groups may be more likely to have complicated mechanisms including a more anteriorly positioned crystalline lens, thicker and more anteriorly inserted iris, and anteriorly rotated ciliary body. This was confirmed partially by our data that PAC/PACG patients had shallower anterior chamber, thicker lens, and greater LT/AL ratio than PACS patients at baseline (Table2), which inferred PAC/PACG participants had a more crowded anterior segment disproportionate to their AL.

Barrett Universal II, Haigis, Holladay 2, Hoffer Q and SRK/T are common IOL power calculation formulae with good performance [17, 18]. However, there are no reports about the accuracy of these formulae when influenced by pharmacological miosis or LPI. Given that TECNIS® Model ZCB00 is a standard monofocal IOL and was commonly used in many comparative studies [1921], the present study chose ZCB00 as a referenced lens to assess the IOL power calculation inconsistency with these interventions.

For the PACS group, the IOL powers predicted by the 3rd generation formulae (i.e., SRK/T and Hoffer Q) did not alter after either miosis or LPI as the variables included in these formulae (i.e., AL and mean K) did not change significantly after either intervention. Besides AL and K, ACD is another parameter incorporated into the 4th generation formula (i.e., Haigis and Holladay 2) which may improve the accuracy of estimating the postoperative lens position. An average of 0.07 mm decrease in ACD in our PACS patients corresponded to around 0.1D lower IOL power prediction according to Olsen T [22], which was consistent with the average 0.08D decreased under miosis calculated by Haigis in our study, although this was probably not a meaningful change in clinical practice. Similarly, the absolute values of the changes in all the related ocular parameters after either miosis or LPI were too small to affect any changes in subsequent IOL power calculation across all the formulae employed.

In the PAC/PACG cohort, AL shortened after LPI by 0.02 mm, with a possible mechanism relating to the significant reduction in intraocular pressure stemming from this intervention (mean reduction of 1.6 mmHg after LPI). Read et al. [23] found that a 1.6 mmHg decline in IOP might predicted a 9.44 μm reduction in AL. In any case, the significant AL reduction of 0.02 mm after LPI in our study would contribute to a negligible 0.055D increase of predicted IOL according to Gullstrand’s model eye. Accordingly, no statistically significant change in IOL power prediction was suggested by various generation formulae after pilocarpine or LPI interventions, except for Holladay 2 that LPI induced an increase of the IOL power prediction by 0.1D compared with baseline. However, either 0.055D or 0.1D increase of IOL power is far from 0.5D which is meaningful to surgeon’s option in clinical practice. Though the IOL power estimation reduced by more than 0.5D under miosis in 0–10% eyes and increased by more than 0.5D after LPI in 2–6% eyes in our study (Supplementary Material2), mainly were still within a change of less than 0.5D and therefore would not affect surgeons’ final decision on IOL power.

Several limitations of the present study should be mentioned. Firstly, IOP was not collected after pilocarpine instillation (T1), so any effect of IOP changes on ocular parameters at this timepoint was unknown. However, based on clinical experience and literatures, pilocarpine or LPI reduces IOP of PACD patients no more than 4 mmHg [2426], which is within the normal range of diurnal variation of IOP in healthy subjects [23], a range that is not expected to influence biometric parameters and the postoperative refractive outcomes significantly [2729]. Secondly, the number of subjects with PACG in our PAC/PACG group was small. Because many PACG patients have had relative extensive angle closure, instead of benefiting from LPI, they are subjected to much higher risk of exposure to higher IOP and disease progression after LPI [30]. Since PAC and PACG have been demonstrated with similar anatomical features [31], we combined PAC and PACG into one group and compared this cohort with PACS in this study. Thirdly, several concentrations of pilocarpine eye drops are commercially available, e.g., 2%, 1.25%, 1%, and 0.5%. Quite a few studies used 2% while some used lower concentrations. Both 1% and 0.5% pilocarpine are commonly used in China and 0.5% is widely used as a maintenance option, that is why we used 0.5% in this study. Whether higher concentration would induce even more significant change of biometric parameters and subsequent IOL power estimations is yet to be elucidated. Lastly, the subjects included in this study have yet to undergo lens extraction, so that we could not assess the mean/median absolute error (MAE/MedAE) for IOL calculation formulae comparison. Although our results demonstrated that neither miosis nor LPI would alter surgeons’ choice of IOL power, subsequent studies in this cohort following cataract surgery would help corroborate these findings.

Conclusion

Both miosis and LPI induced significant changes on anterior segment parameters; but ultimately did not affect the IOL power calculations predicted for emmetropia. Other avenues which may potentially explain postoperative refractive error warrant further investigation in the PACD cohort.

Summary

What was known before

  • Cataract surgery is an established treatment for PACD patients with lens opacity. However, the refractive outcomes after cataract surgery in PACD patients are not as precise compared to the general population undergoing cataract surgery.

  • Pilocarpine and laser peripheral iridotomy (LPI) are two commonly used interventions in PACD patients, both of which may affect ocular biometrics.

What this study adds

  • Pharmacological miosis and LPI significantly alter ocular biometrics but do not alter IOL calculation predicted for emmetropia with commonly used SRK/T, Hoffer Q, Haigis, Holladay 2 and Barrett Universal II formulae in PACD.

  • Other factors accounting for increased postoperative refractive error warrant further investigation in PACD patients.

Supplementary information

Supplementary material 1(22K, docx)

Supplementary material 2(18K, docx)

Author contributions

XS and YC conceived and designed the work. HY and DQ majorly carried out this clinic trial and acquired data. JW, GC and HY played an important role in data analysis and results interpretation. HY, GC and YC drafted and revised the manuscript. All the authors approved the final version to be published.

Funding

This research project was supported directly by Shanghai Municipal Health Commission (20214Y0073), Clinical Research Plan of SHDC (Grant No. SHDC2020CR6029). The authors were also supported by grants from the State Program of National Natural Science Foundation of China (81870692), Shanghai Committee of Science and Technology (Grant no. 20S31905800), National Key Research and Development Program of China (2020YFA0112700), the State Key Program of National Natural Science Foundation of China (82030027), the subject of major projects of National Natural Science Foundation of China (81790641), and National Natural Science Foundation of China (82101123).

Data availability

The datasets generated and analysed during the current study are available from the corresponding author, YHC, on reasonable request. The data are not publicly available due to their containing information that could compromise the privacy of research participants.

Competing interests

The authors declare no competing interests.

Footnotes

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Xinghuai Sun, Email: nc.ude.umhs@nushx.

Yuhong Chen, Email: nc.ude.naduf@nehcgnohuy.

Supplementary information

The online version contains supplementary material available at 10.1038/s41433-023-02408-z.

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Influence of miosis and laser peripheral iridotomy on intraocular lens power calculation in patients with primary angle closure disease (2024)

FAQs

Influence of miosis and laser peripheral iridotomy on intraocular lens power calculation in patients with primary angle closure disease? ›

Conclusion. Both miosis and LPI induced significant changes on anterior segment parameters; but ultimately did not affect the IOL power calculations predicted for emmetropia.

How does Miosis decrease intraocular pressure? ›

As an initial option for primary ACG treatment, miotics could induce the contraction of the sphincter pupillae, which could then pull the peripheral iris away from the trabecular meshwork and therefore reopen the angle, and finally decrease intraocular pressure (IOP) and control the progression of glaucoma.

What is the success rate of laser iridotomy for narrow angles? ›

Laser iridotomy is usually very successful, but it can fail to sufficiently open the angle in about one out of four cases. Depending on the factors of the case, patients might need more laser treatment, medications, or surgery.

Why is my eye pressure still high after an iridotomy? ›

This side effect occurs because iris pigment is released when the hole is created with the laser. The pigment can temporarily clog the drainage system, and cause the eye pressure to increase. For this reason, you will be asked to wait 30-60 minutes after the procedure so that your eye pressure can be rechecked.

What are the visual disturbances after iridotomy? ›

If the patient experiences visual disturbance, a color contact lens may be placed to block light entering through the iridotomy. All narrow angles should be treated with an LPI to prevent acute angle closure from pupillary block.

Does pupil dilation affect IOP? ›

Results. We observed a significant increase in IOP after dilation, 1.85 ± 2.01 mmHg (p = 0.002). IOP elevation remained significant until about four hours after dilation. Thereafter, IOP decreased slowly and eventually reached pre-dilation level (p > 0.05).

What decreases intraocular pressure? ›

The medications available for reducing IOP in glaucoma patients include topical β-adrenergic antagonists (eg, timolol, betaxolol), carbonic anhydrase inhibitors (eg, dorzolamide, brinzolamide), cholinergics (eg, pilocarpine), α-adrenergic agonists (eg, brimonidine), prostaglandins (eg, latanoprost, travoprost), and ...

What is the most common complication of iridotomy? ›

Anterior Chamber Bleeding (Hyphema)

Ii is a common complication post-LPI. It refers to bleeding from the iridotomy site, is minor in most cases and can usually be stopped by light pressure applied to the eye with the contact lens.

What are the long term effects of laser iridotomy? ›

Long term effects of laser PI include: cataract formation, visual dysphotopsias (glares, halos, lines, spots). These side effects are rare (< 2%). The majority of visual dysphotopsias are likely to resolve after 6 months, indicating that patients adopt or learn to ignore images.

Can vision improve after iridotomy? ›

The results of laser iridotomy can often be seen almost immediately after the procedure, with many patients experiencing significant improvement in their vision and pressure within a few days. Patients should see an ophthalmologist after to ensure that they do not experience any problems related to the surgery.

How much does a laser iridotomy cost? ›

On MDsave, the cost of a Laser Iridotomy ranges from $1,134 to $1,810. Those on high deductible health plans or without insurance can shop, compare prices and save. Read more about how MDsave works.

Can you see the hole after iridotomy? ›

It's pretty uncommon that you or someone else will see where the hole was made, though if you look closely, you'll later possibly see a black dot where it is.

Does iridotomy damage cornea? ›

Although it has been demonstrated to be a relatively safe procedure, there is still the potential long-term risk of corneal decompensation, for which a corneal transplantation may be indicated eventually. The longest interval between laser iridotomy and corneal decompensation reported was 8 years.

What is a ghost image after laser iridotomy? ›

Patients sometimes report visual complications including visually perceptible lines, ghost images, glare, or monocular blurring after iridotomy.

Is laser iridotomy really necessary? ›

It is recommended in eyes which have the angle closed for at least half the eye and have high eye pressure or glaucoma. In eyes which have a closed angle but normal eye pressure and no optic nerve damage, laser iridotomy may be recommended as a preventive treatment.

Can iridotomy cause blindness? ›

The chance of losing vision following a laser procedure is extremely small. The main risks of a laser iridotomy are that your iris might be difficult to penetrate, requiring more than one treatment session. The other risk is that the hole in your iris will close. This happens less than one-third of the time.

How do cholinergic miotics reduce intraocular pressure? ›

In addition to constricting the pupil, cholinergic miotics may also reduce intraocular pressure by increasing the outflow of aqueous humor. Agents such as tamsulosin that act as antagonists at alpha (α1) receptors may induce miosis by relaxing the dilator pupillae (Table 2.4).

How does pupil constriction help glaucoma? ›

It works by constricting the pupil and tightening the tension of the iris, which helps open the angle between the iris and cornea, facilitating aqueous humor drainage. Pilocarpine is usually administered once the intraocular pressure is below 40 mm Hg.

Does tropicamide affect intraocular pressure? ›

Elevation of intraocular pressure by many cycloplegic drugs has been reported to occur in eyes in which the filtration angle remained open during mydriasis. Tropicamide 1% is also capable of this phenomenon in patients with open angle glaucoma who are being medicated with pilocarpine.

Why does mydriasis increased intraocular pressure? ›

An elevation in IOP level has been observed after pharmacological mydriasis. This IOP rise following pupillary dilatation may be attributed to the reduction in aqueous outflow secondary to the decreased traction on the trabecular meshwork resulting from ciliary muscle paralysis.

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